Contact Information

Department of Computing Sciences
Bocconi University

Via Guglielmo Röntgen 1

20136 Milan, Italy


Journal papers


Tangherloni A, Riva SG, Myers B, Buffa FM, Cazzaniga P. MAGNETO: Marker pAnels GeNEraTor with multi-Objective optimization. Journal of Biomedical Informatics, accepted

Papetti DM, Tangherloni A, Farinati D, Cazzaniga P, Vanneschi L. Simplifying Fitness Landscapes using Dilation Functions evolved with Genetic Programming. IEEE Computational Intelligence Magazine, 18(1): 22-31.

DOI: 10.1109/MCI.2022.3222096




Riva SG, Cazzaniga P, Nobile MS, Spolaor S, Rundo L, Besozzi D, Tangherloni A. SMGen: A generator of synthetic models of biochemical reaction networks. Symmetry, 14(1): 119.
DOI: 10.3390/sym14010119


Castelli M, Manzoni L, Mariot L, Nobile MS, Tangherloni A. Salp Swarm Optimization: a Critical Review. Expert Systems with Applications, 189: 116029. DOI: 10.1016/j.eswa.2021.116029




​​Tangherloni A, Nobile MS, Cazzaniga P, Capitoli G, Spolaor S, Rundo L, Mauri G, Besozzi D. FiCoS: a fine- and coarse-grained GPU-powered deterministic simulator for biochemical networks. PLoS Computational Biology, 17(9): e1009410. DOI: 10.1371/journal.pcbi.1009410

Tangherloni A, Ricciuti F, Besozzi D, Liò P, Cvejic A. Analysis of single-cell RNA sequencing data based on autoencoders. BMC Bioinformatics, 22(1): 309.
DOI: 10.1186/s12859-021-04150-3

Rundo L*, Tangherloni A*, Cazzaniga P, Mistri M, Galimberti S, Woitek R, Sala E, Mauri G, Nobile MS. A CUDA-powered method for the feature extraction and unsupervised analysis of medical images. The Journal of Supercomputing. DOI: 10.1007/s11227-020-03565-8 (* equal contribution) 

Ranzoni AM*, Tangherloni A*, Berest I, Riva SG, Myers B, Strzelecka PM, Xu J, Panada E, Mohorianu I, Zaugg JB, Cvejic A. Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis. Cell Stem Cell. DOI: 10.1016/j.stem.2020.11.015 (* equal contribution)




Rundo L*, Tangherloni A*, Tyson DR*, Betta R, Militello C, Spolaor S, Nobile MS, Besozzi D, Lubbock ALR, Quaranta V, Mauri G, Lopez CF, Cazzaniga P. ACDC: Automated cell detection and counting for time-lapse fluorescence microscopy. Applied Sciences, 10(18), 6187. DOI: 10.3390/app10186187 (* equal contribution)


Besozzi D, Manzoni L, Nobile MS, Spolaor S, Castelli M, Vanneschi L, Cazzaniga P, Ruberto S, Rundo L, Tangherloni A. Computational Intelligence for Life Sciences. Fundamenta Informaticae, 171(1-4), 57-80.
DOI: 10.3233/FI-2020-1872 




Tangherloni A, Spolaor S, Cazzaniga P, Besozzi D, Rundo L, Mauri G, Nobile MS. Biochemical parameter estimation vs. benchmark functions: A comparative study of optimization performance and representation design. Applied Soft Computing, 81: 105494.
DOI: 10.1016/j.asoc.2019.105494

Rundo L*, Tangherloni A*, Cazzaniga P, Nobile MS, Russo G, Gilardi MC, Vitabile S, Mauri G, Besozzi D, Militello C. A novel framework for MR image segmentation and quantification by using MedGA. Computer Methods and Programs in Biomedicine, 176(1): 59-172.
DOI: 10.1016/j.cmpb.2019.04.016 (* equal contribution)

Rundo L*, Tangherloni A*, Nobile MS, Militello C, Besozzi D, Mauri G, Cazzaniga P. MedGA: A Novel Evolutionary Method for Medical Image Enhancement in Medical Imaging Systems. Expert Systems with Applications, 119: 387-399. DOI: 10.1016/j.eswa.2018.11.013
(* equal contribution)

Tangherloni A, Spolaor S, Rundo L, Nobile MS, Cazzaniga P, Mauri G, Liò P, Merelli I, Besozzi D. GenHap: A Novel Computational Method Based on Genetic Algorithms for Haplotype Assembly. BMC Bioinformatics, 20(4): 172. DOI: 10.1186/s12859-019-2691-y

Rundo L, Han C, Nagano Y, Zhang J, Hataya R, Militello C, Tangherloni A, Nobile MS, Ferretti C, Besozzi D, Gilardi MC, Vitabile S, Mauri G, Nakayama H, Cazzaniga P. USE-Net: Incorporating Squeeze-and-Excitation blocks into U-Net for prostate zonal segmentation of multi-institutional MRI datasets. Neurocomputing, 365: 31-43.
DOI: 10.1016/j.neucom.2019.07.006




Rundo L, Militello C, Tangherloni A, Russo G, Vitabile S, Gilardi MC, Mauri G. NeXt for neuro‐radiosurgery: A fully automatic approach for necrosis extraction in brain tumor MRI using an unsupervised machine learning technique. International Journal of Imaging Systems and Technology, 28(1): 21-37. DOI: 10.1002/ima.22253




Tangherloni A, Nobile MS, Besozzi D, Mauri G, Cazzaniga P. LASSIE: simulating large-scale models of biochemical systems on GPUs. BMC Bioinformatics, 18(1): 246.
DOI: 10.1186/s12859-017-1666-0


Tangherloni A, Nobile MS, Cazzaniga P, Besozzi D, Mauri G. Gillespie’s Stochastic Simulation Algorithm on MIC Coprocessor. The Journal of Supercomputing, 73(2): 676-686. DOI: 10.1007/s11227-016-1778-8

Nobile MS, Cazzaniga P, Tangherloni A, Besozzi D. Graphics Processing Units in Bioinformatics, Computational Biology and Systems Biology. Briefings in Bioinformatics, 18(5): 870-885. DOI: 10.1093/bib/bbw058

+39 02 5836


Research Interests

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